ABSTRACT
Despite a high prevalence of common mental health concerns, especially among young adults, majority of them do not seek professional help. This study explored perceived barriers and enablers of professional help-seeking for common mental health concerns among distressed non-treatment seeking young adults in the urban Indian context. The study utilized an explanatory sequential mixed methods design. A brief survey was conducted with distressed non-treatment seeking young adults (N=37) to assess their current distress level, duration, perceived severity, effect on functioning, self-help methods, past treatment history, inclination to seek help and barriers to professional help-seeking. Semi-structured interviews were conducted with a sub-sample of 10 participants to explore their perceived barriers and potential enablers of professional help-seeking. Quantitative data were analyzed using descriptive statistics and interviews using thematic analysis. The survey revealed significant distress for 75.7% (N=28) of the total sample. Out of these, 25% were either not inclined or had practical constraints to seek help. The mean score for inclination to seek help was highest for partner/friend (4.7). Qualitative findings have been discussed under personal and general barriers and enablers. This is the first study to highlight the complex interplay of barriers and enablers of professional help-seeking among distressed non-treatment seeking young adults in the urban Indian context. There is an urgent need to incorporate the factors that hinder and facilitate professional help-seeking while devising help-seeking interventions to reduce the treatment gap.
ABSTRACT
Background: Intracholecystic papillary–tubular neoplasm (ICPN) is a relatively new entity which includes neoplastic polyps, adenomas, and papillary neoplasms that are ?1.0 cm. This study is done to evaluate the pathological features of ICPN and to find out the factors associated with invasion. Materials and Methods: This is a 5-year retrospective study in a referral pathology center. A total of 19 cases of ICPN are found. The cases are analyzed for age and sex distribution, clinical suspicion, stages, histological architecture, differentiation, and grade of dysplasia. Descriptive statistics and test of significance by Chi-square and t-test are used in the study. Results: ICPN comprises 23.5% of all gallbladder neoplasms. Two-thirds of the cases were suspected radiologically. Age range is 26–65 years with mean age of 50 years. They are 2.8 times more common in female. Approximately one-third of the cases show invasion. The most common histological pattern is papillary, followed by papillary–tubular and finally by tubular pattern. Pyloric and biliary are the most common differentiation pattern followed by oncocytic and intestinal pattern. About three-fourths of the cases are associated with high-grade dysplasia mostly diffuse high-grade dysplasia. Conclusion: We have found the younger age of presentation, less proportion of invasive tumors, fewer tumors with biliary phenotypes, and fewer tumors with high-grade dysplasia as compared to previous studies. Factors significantly associated with invasion are grade and extent of dysplasia particularly diffuse high-grade dysplasia.
ABSTRACT
Tuberculosis is an infectious disease that has displayed increasing incidence in the last decades. In the ENT area, the most common onset is cervical lymphadenitis, which accounts for 95% of ENT cases. The posterior pharyngeal wall, tonsillar pillars, sidewalls, soft palate, and tongue are the least probable locations. A 40 year old male presented in the ENT OPD with a growth at base of tongue, involving the lateral sulcus, anterior tonsillar pillar and lower pole of tonsil left side. A biopsy was taken from the same area and sent for histopathological examination with a strong clinical suspicion of squamous cell carcinoma. The final histopathological diagnosis was tuberculosis of tongue. The patient showed good response on ATT.
ABSTRACT
Insulin, Glibenclamide and Tolbutamide are some of the frequently used drugs for the most common metabolic disorders, diabetes mellitus. Along with hypoglycaemic drugs diabetic patient is exposed to variety of drugs. NSAIDs are one of the commonly used drugs in this metabolic syndrome. When a patient on hypoglycaemic drugs receives NSAIDs there are chances of drug interactions. This study was undertaken in the department of Pharmacology, GSVM medical college, Kanpur (UP) after approval by the institutional animal ethics committee to find out the interaction if any between Diclofenac and three hypoglycaemic drugs i.e. insulin, glibenclamide and tolbutamide. Young healthy rabbits were divided into six groups: five rabbits in each group. First group received Insulin 1 u/kg subcutaneously; second Glibenclamide 0.05 mg/kg orally; third Tolbutamide 40 mg/kg orally; fourth Diclofenac 1mg/kg orally and insulin 1mg/kg s.c. simultaneously; fifth glibenclamide 0.05mg/kg orally at 0 hour and diclofenac 1mg/kg orally at 2 hours and sixth tolbutamide 40mg/kg orally at 0 hour and diclofenac 1mg/kg orally at 2 hours. Blood samples were taken at 0, 1, 2, 4 and 6 hours for blood sugar estimation. Mean blood sugar levels reduced significantly from their fasting levels when insulin, glibenclamide and tolbutamide were administered. However blood sugar levels did not showed any significant changes when diclofenac was administered along with insulin, glibenclamide and tolbutamide in comparison to when insulin, glibenclamide and tolbutamide were given alone. The results showed that diclofenac does not interact with insulin, glibenclamide and tolbutamide on blood sugar levels in rabbits.